Relationship between paternal somatic health and assisted reproductive technology outcomes

Michael L. Eisenberg, Shufeng Li, Lauren A. Wise, Courtney D. Lynch, Steven Nakajima, Stuart A. Meyers, Barry Behr, Valerie L. Baker

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective To study the association between paternal medical comorbidities and the outcomes of assisted reproductive technology (ART). Design Retrospective cohort study. Setting Academic reproductive medicine center. Patient(s) We analyzed fresh ART cycles uszing freshly ejaculated sperm from the male partner of couples undergoing ART cycles from 2004 until 2014. We recorded patient and partner demographic characteristics. The cohort was linked to hospital billing data to obtain information on selected male partners' comorbidities identified using ICD-9-CM codes. Intervention(s) None. Main Outcome Measure(s) Fertilization, clinical pregnancy, miscarriage, implantation, and live-birth rates as well as birth weights and gestational ages. Result(s) In all, we identified 2,690 men who underwent 5,037 fresh ART cycles. Twenty-seven percent of men had at least one medical diagnosis. Men with nervous system diseases had on average lower pregnancy rates (23% vs. 30%) and live-birth rates (15% vs. 23%) than men without nervous system diseases. Lower fertilization rates were also observed among men with respiratory diseases (61% vs. 64%) and musculoskeletal diseases (61% vs. 64%) relative to those without these diseases. In addition, men with diseases of the endocrine system had smaller children (2,970 vs. 3,210 g) than men without such diseases. Finally, men with mental disorders had children born at an earlier gestational age (36.5 vs. 38.0 weeks). Conclusion(s) The current report identified a possible relationship between a man's health history and IVF outcomes. As these are potentially modifiable factors, further research should determine whether treatment for men's health conditions may improve or impair IVF outcomes.

Original languageEnglish (US)
Pages (from-to)559-565
Number of pages7
JournalFertility and sterility
Issue number3
StatePublished - Sep 1 2016
Externally publishedYes


  • Male infertility
  • comorbidity
  • fertilization in vitro
  • health

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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