Relationship between neuropsychological behavior and brain white matter in first-episode psychosis

Andreia V. Faria; Jeffrey Crawford; Chenfei Ye; Johnny Hsu; Anshel Kenkare; David Schretlen; Akira Sawa

doi:10.1016/j.schres.2019.04.010

Relationship between neuropsychological behavior and brain white matter in first-episode psychosis

Andreia V. Faria
, Jeffrey Crawford
, Chenfei Ye
, Johnny Hsu
, Anshel Kenkare
, David Schretlen
, Akira Sawa

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).

Original language	English (US)
Pages (from-to)	49-54
Number of pages	6
Journal	Schizophrenia Research
Volume	208
DOIs	https://doi.org/10.1016/j.schres.2019.04.010
State	Published - Jun 2019

Keywords

Cognition
DTI
First-episode psychosis
MRI
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2019.04.010

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title = "Relationship between neuropsychological behavior and brain white matter in first-episode psychosis",

abstract = "We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).",

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doi = "10.1016/j.schres.2019.04.010",

language = "English (US)",

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T1 - Relationship between neuropsychological behavior and brain white matter in first-episode psychosis

AU - Faria, Andreia V.

AU - Crawford, Jeffrey

AU - Ye, Chenfei

AU - Hsu, Johnny

AU - Kenkare, Anshel

AU - Schretlen, David

AU - Sawa, Akira

PY - 2019/6

Y1 - 2019/6

N2 - We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).

AB - We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).

KW - Cognition

KW - DTI

KW - First-episode psychosis

KW - MRI

KW - Schizophrenia

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DO - 10.1016/j.schres.2019.04.010

M3 - Article

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AN - SCOPUS:85064220449

SN - 0920-9964

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SP - 49

EP - 54

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Relationship between neuropsychological behavior and brain white matter in first-episode psychosis

Abstract

Keywords

ASJC Scopus subject areas

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