Relationship between bone cross-sectional area and indices of peripheral artery disease

Claudio Pedone, Simone Scarlata, Nicola Napoli, Fulvio Lauretani, Stefania Bandinelli, Luigi Ferrucci, Raffaele Antonelli Incalzi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Most studies on the relationship between bone mineral density and atherosclerosis have used dual-energy X-ray absorptiometry, but this method is relatively insensitive to bone geometry. The aim of this study was to investigate the relationship between bone area and indices of carotid and peripheral atherosclerosis. We studied 841 persons aged 65 years or older (women = 444, mean age 73.8 years; men = 397, mean age = 75.3 years) enrolled in the InCHIANTI study and free from active malignancies, chronic use of bisphosphonates or steroids, and estrogen replacement therapy. The tibial cortical and total cross-sectional area (CSA) were measured by peripheral quantitative computed tomography and their ratio was calculated (cortical/total cross-sectional area ratio, cCSA/tCSA); carotid plaques were screened by echography, and peripheral artery disease (PAD) was defined as an ankle/brachial index

Original languageEnglish (US)
Pages (from-to)508-516
Number of pages9
JournalCalcified Tissue International
Issue number6
StatePublished - Dec 2013
Externally publishedYes


  • Atherosclerosis
  • Bone cross-sectional area
  • Elderly
  • Osteoporosis
  • Peripheral artery disease
  • Women

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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