Relationship between anorectic and reinforcing properties of appetite suppressant drugs: Implications for assessment of abuse liability

R. R. Griffiths; J. V. Brady; J. D. Snell

Relationship between anorectic and reinforcing properties of appetite suppressant drugs: Implications for assessment of abuse liability

R. R. Griffiths, J. V. Brady, J. D. Snell

Johns Hopkins Bayview Hospital

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A quantitative ratio measure was developed with permitted comparisons between the reinforcing and anorectic potency of eight phenylethylamine anorectics and cocaine in laboratory baboons. The ordering of these compounds based upon this ratio bears a reasonable correspondence to clinical drug evaluations. The measure may provide information for preclinical evaluation of relative abuse potential of anorectic drugs.

Original language	English (US)
Pages (from-to)	283-290
Number of pages	8
Journal	Biological psychiatry
Volume	13
Issue number	2
State	Published - 1978

ASJC Scopus subject areas

Biological Psychiatry

Cite this

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title = "Relationship between anorectic and reinforcing properties of appetite suppressant drugs: Implications for assessment of abuse liability",

abstract = "A quantitative ratio measure was developed with permitted comparisons between the reinforcing and anorectic potency of eight phenylethylamine anorectics and cocaine in laboratory baboons. The ordering of these compounds based upon this ratio bears a reasonable correspondence to clinical drug evaluations. The measure may provide information for preclinical evaluation of relative abuse potential of anorectic drugs.",

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ER -

Relationship between anorectic and reinforcing properties of appetite suppressant drugs: Implications for assessment of abuse liability

Abstract

ASJC Scopus subject areas

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