Relation of C-Reactive Protein to Coronary Collaterals in Patients With Stable Angina Pectoris and Coronary Artery Disease

Arthur Kerner, Luis Gruberg, Alexander Goldberg, Ariel Roguin, Peretz Lavie, Lena Lavie, Walter Markiewicz, Rafael Beyar, Doron Aronson

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The heterogeneity in the degree of collateralization among patients with coronary artery disease (CAD) is poorly understood. We sought to determine whether chronic subclinical inflammation is related to coronary collateral development in patients with chronic stable angina pectoris and obstructive CAD. High-sensitivity C-reactive protein (CRP) levels were measured in 177 patients with stable angina pectoris before coronary angiography. Multivariable logistic regression revealed an inverse graded association between CRP and the presence of coronary collaterals (Rentrop grade 1 to 3). Compared with patients in the first CRP tertile, the adjusted odds ratio for the presence of coronary collaterals was 0.70 (95% confidence interval, 0.33 to 1.52; p = 0.45) for patients in the second CRP tertile and 0.33 (95% confidence interval, 0.15 to 0.75; p = 0.008) for patients in the third CRP tertile (p for trend = 0.008). In conclusion, an inverse graded association exists between CRP and the presence of coronary collaterals in patients with stable angina pectoris.

Original languageEnglish (US)
Pages (from-to)509-512
Number of pages4
JournalThe American Journal of Cardiology
Volume99
Issue number4
DOIs
StatePublished - Feb 15 2007
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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