Relation of BMI and waist circumference with the risk of new-onset hyperuricemia in hypertensive patients

Q. Li, R. Li, S. Zhang, Y. Zhang, M. Liu, Y. Song, C. Liu, L. Liu, X. Wang, B. Wang, X. Xu, X. Qin

Research output: Contribution to journalArticlepeer-review


Background: We aimed to evaluate the relationship of body mass index (BMI) and waist circumference (WC) with the risk of new-onset hyperuricemia, and examine possible effect modifies in general hypertensive patients. Methods: A total of 10 611 hypertensive patients with normal uric acid (UA) concentrations (<357 lmol/l) at baseline were included from the UA sub-study of the China Stroke Primary Prevention Trial. The primary outcome was new-onset hyperuricemia, defined as a UA concentration 417 lmol/l in men or 357 lmol/l in women at the exit visit. Results: During a median follow-up duration of 4.4 years, 1663 (15.7%) participants developed new-onset hyperuricemia. When analyzed separately, increased BMI (25 kg/m2 , quartile 3–4; OR, 1.46; 95% CI: 1.29–1.65), or increased WC (85 cm for females, quartile 3–4; OR, 1.24; 95% CI: 1.08–1.42; and 84 cm for males, quartile 3–4; OR, 1.30; 95% CI: 1.01–1.67) were each significantly associated with higher risk of new-onset hyperuricemia. When WC was forced into the model with BMI simultaneously, its significant association with new-onset hyperuricemia disappeared in females (<85 vs. 85 cm; OR, 0.96, 95% CI: 0.81–1.13) or males (84 vs. <84 cm; OR, 1.13; 95% CI: 0.84–1.52); however, BMI was still significantly related with new-onset hyperuricemia (25 vs. <25 kg/m2; OR, 1.48; 95% CI: 1.27–1.73). Moreover, the positive BMI & new-onset hyperuricemia association was more pronounced in participants with higher time-averaged on-treatment systolic blood pressure (median: <138.3 vs. 138.3 mmHg; P-interaction.041). Conclusions: Higher BMI, but not WC, is significantly and independently associated with an increased risk of new-onset hyperuricemia among hypertensive patients.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
Issue number5
StatePublished - May 1 2022

ASJC Scopus subject areas

  • General Medicine


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