Relapsing, remitting hypercortisolism in Cushing's disease due to intratumoral hemorrhages in pituitary microadenoma

Nicholas F. Marko; Amir H. Hamrahian; Betul Hatipoglu; Robert J. Weil

doi:10.1016/j.jocn.2012.05.039

Relapsing, remitting hypercortisolism in Cushing's disease due to intratumoral hemorrhages in pituitary microadenoma

Nicholas F. Marko, Amir H. Hamrahian, Betul Hatipoglu, Robert J. Weil

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We report two patients with Cushing's disease (CD) from adrenocorticotropic hormone-secreting microadenomas in whom intralesional hemorrhage caused an episodic, remitting and relapsing pattern of hypercortisolism. To our knowledge this is the first report of patients in whom hemorrhage within a microadenoma caused cyclic CD. Both patients were treated successfully with transsphenoidal surgery.

Original language	English (US)
Pages (from-to)	753-756
Number of pages	4
Journal	Journal of Clinical Neuroscience
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/j.jocn.2012.05.039
State	Published - May 2013
Externally published	Yes

Keywords

Adrenocorticotropic hormone
Apoplexy
Cortisol
Cushing's syndrome
Cyclic Cushing disease
Pituitary surgery
Transsphenoidal

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.jocn.2012.05.039

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title = "Relapsing, remitting hypercortisolism in Cushing's disease due to intratumoral hemorrhages in pituitary microadenoma",

abstract = "We report two patients with Cushing's disease (CD) from adrenocorticotropic hormone-secreting microadenomas in whom intralesional hemorrhage caused an episodic, remitting and relapsing pattern of hypercortisolism. To our knowledge this is the first report of patients in whom hemorrhage within a microadenoma caused cyclic CD. Both patients were treated successfully with transsphenoidal surgery.",

keywords = "Adrenocorticotropic hormone, Apoplexy, Cortisol, Cushing's syndrome, Cyclic Cushing disease, Pituitary surgery, Transsphenoidal",

author = "Marko, {Nicholas F.} and Hamrahian, {Amir H.} and Betul Hatipoglu and Weil, {Robert J.}",

note = "Funding Information: NFM is supported by a grant from the American Association of Neurological Surgeons William P. VanWagenen Fellowship Program. RJW is supported, in part, by the Melvin Burkhardt Chair in Neurosurgical Oncology and the Karen Colina Wilson Research Endowment within the Brain Tumor and Neuro-oncology Center at the Cleveland Clinic Foundation.",

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doi = "10.1016/j.jocn.2012.05.039",

language = "English (US)",

volume = "20",

pages = "753--756",

journal = "Journal of Clinical Neuroscience",

issn = "0967-5868",

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T1 - Relapsing, remitting hypercortisolism in Cushing's disease due to intratumoral hemorrhages in pituitary microadenoma

AU - Marko, Nicholas F.

AU - Hamrahian, Amir H.

AU - Hatipoglu, Betul

AU - Weil, Robert J.

N1 - Funding Information: NFM is supported by a grant from the American Association of Neurological Surgeons William P. VanWagenen Fellowship Program. RJW is supported, in part, by the Melvin Burkhardt Chair in Neurosurgical Oncology and the Karen Colina Wilson Research Endowment within the Brain Tumor and Neuro-oncology Center at the Cleveland Clinic Foundation.

PY - 2013/5

Y1 - 2013/5

N2 - We report two patients with Cushing's disease (CD) from adrenocorticotropic hormone-secreting microadenomas in whom intralesional hemorrhage caused an episodic, remitting and relapsing pattern of hypercortisolism. To our knowledge this is the first report of patients in whom hemorrhage within a microadenoma caused cyclic CD. Both patients were treated successfully with transsphenoidal surgery.

AB - We report two patients with Cushing's disease (CD) from adrenocorticotropic hormone-secreting microadenomas in whom intralesional hemorrhage caused an episodic, remitting and relapsing pattern of hypercortisolism. To our knowledge this is the first report of patients in whom hemorrhage within a microadenoma caused cyclic CD. Both patients were treated successfully with transsphenoidal surgery.

KW - Adrenocorticotropic hormone

KW - Apoplexy

KW - Cortisol

KW - Cushing's syndrome

KW - Cyclic Cushing disease

KW - Pituitary surgery

KW - Transsphenoidal

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Relapsing, remitting hypercortisolism in Cushing's disease due to intratumoral hemorrhages in pituitary microadenoma

Abstract

Keywords

ASJC Scopus subject areas

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