Relapsing Anti-GAD65-Associated Encephalitis Responsive to Thymoma Resection, Radiation, and Immunomodulatory Therapy

Jonathan D. Krett; Maria E. Molinaro; Justin C. McArthur; David O. Kamson; Kemar E. Green; John C. Probasco

doi:10.1177/19418744241239099

Relapsing Anti-GAD65-Associated Encephalitis Responsive to Thymoma Resection, Radiation, and Immunomodulatory Therapy

Jonathan D. Krett, Maria E. Molinaro, Justin C. McArthur, David O. Kamson, Kemar E. Green, John C. Probasco

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Herein we describe a case of relapsing anti-GAD65-associated encephalitis which was responsive to the combination of thymoma resection, external beam radiotherapy, and immunomodulatory therapy. The case illustrates the value of remaining vigilant for the possibility of paraneoplastic syndromes in the context of anti-GAD65 antibodies and thymoma. It also illustrates that tumor-directed therapies may offer additional benefit beyond immunomodulatory therapy alone.

Original language	English (US)
Pages (from-to)	363-365
Number of pages	3
Journal	Neurohospitalist
Volume	14
Issue number	3
DOIs	https://doi.org/10.1177/19418744241239099
State	Published - Jul 2024

Keywords

imaging
nervous system
neuroimmunology
paraneoplastic syndromes

ASJC Scopus subject areas

Clinical Neurology

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10.1177/19418744241239099

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abstract = "Herein we describe a case of relapsing anti-GAD65-associated encephalitis which was responsive to the combination of thymoma resection, external beam radiotherapy, and immunomodulatory therapy. The case illustrates the value of remaining vigilant for the possibility of paraneoplastic syndromes in the context of anti-GAD65 antibodies and thymoma. It also illustrates that tumor-directed therapies may offer additional benefit beyond immunomodulatory therapy alone.",

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author = "Krett, {Jonathan D.} and Molinaro, {Maria E.} and McArthur, {Justin C.} and Kamson, {David O.} and Green, {Kemar E.} and Probasco, {John C.}",

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AU - Molinaro, Maria E.

AU - McArthur, Justin C.

AU - Kamson, David O.

AU - Green, Kemar E.

AU - Probasco, John C.

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/7

Y1 - 2024/7

N2 - Herein we describe a case of relapsing anti-GAD65-associated encephalitis which was responsive to the combination of thymoma resection, external beam radiotherapy, and immunomodulatory therapy. The case illustrates the value of remaining vigilant for the possibility of paraneoplastic syndromes in the context of anti-GAD65 antibodies and thymoma. It also illustrates that tumor-directed therapies may offer additional benefit beyond immunomodulatory therapy alone.

AB - Herein we describe a case of relapsing anti-GAD65-associated encephalitis which was responsive to the combination of thymoma resection, external beam radiotherapy, and immunomodulatory therapy. The case illustrates the value of remaining vigilant for the possibility of paraneoplastic syndromes in the context of anti-GAD65 antibodies and thymoma. It also illustrates that tumor-directed therapies may offer additional benefit beyond immunomodulatory therapy alone.

KW - imaging

KW - nervous system

KW - neuroimmunology

KW - paraneoplastic syndromes

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Relapsing Anti-GAD65-Associated Encephalitis Responsive to Thymoma Resection, Radiation, and Immunomodulatory Therapy

Abstract

Keywords

ASJC Scopus subject areas

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