Relapse as histoid leprosy after receiving multidrug therapy (MDT); a report of three cases

Issac N. Shaw; Gigi Ebenezer; Geetha S. Rao; Mani Mozhi Natrajan; Babu Balasundaram

Relapse as histoid leprosy after receiving multidrug therapy (MDT); a report of three cases

Issac N. Shaw, Gigi Ebenezer, Geetha S. Rao, Mani Mozhi Natrajan, Babu Balasundaram

Research output: Contribution to journal › Article › peer-review

Abstract

The histoid type of leprosy has been described as occurring in lepromatous leprosy patients who relapse after many years of apparently successful dapsone monotherapy. Three patients who had received the World Health Organization-recommended regimens of multidrug therapy (WHO/ MDT) relapsed as histoid leprosy 12-15 years after completion of treatment. In one patient, through mouse foot pad studies, the bacilli were found to be sensitive to rifampin and clofazimine and resistant to dapsone. In the other two patients mouse foot pad studies were inconclusive. The patients were re-started on WHO/ MDT. Two patients took regular treatment and improved, both clinically and bacteriologically. One patient was irregular in treatment, and 1 year after re-starting WHO/ MDT nodules were still present although the bacterial index had fallen slightly.

Original language	English (US)
Pages (from-to)	272-276
Number of pages	5
Journal	International Journal of Leprosy and Other Mycobacterial Diseases
Volume	68
Issue number	3
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Dermatology

Cite this

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title = "Relapse as histoid leprosy after receiving multidrug therapy (MDT); a report of three cases",

abstract = "The histoid type of leprosy has been described as occurring in lepromatous leprosy patients who relapse after many years of apparently successful dapsone monotherapy. Three patients who had received the World Health Organization-recommended regimens of multidrug therapy (WHO/ MDT) relapsed as histoid leprosy 12-15 years after completion of treatment. In one patient, through mouse foot pad studies, the bacilli were found to be sensitive to rifampin and clofazimine and resistant to dapsone. In the other two patients mouse foot pad studies were inconclusive. The patients were re-started on WHO/ MDT. Two patients took regular treatment and improved, both clinically and bacteriologically. One patient was irregular in treatment, and 1 year after re-starting WHO/ MDT nodules were still present although the bacterial index had fallen slightly.",

author = "Shaw, {Issac N.} and Gigi Ebenezer and Rao, {Geetha S.} and Natrajan, {Mani Mozhi} and Babu Balasundaram",

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AU - Shaw, Issac N.

AU - Ebenezer, Gigi

AU - Rao, Geetha S.

AU - Natrajan, Mani Mozhi

AU - Balasundaram, Babu

PY - 2000

Y1 - 2000

N2 - The histoid type of leprosy has been described as occurring in lepromatous leprosy patients who relapse after many years of apparently successful dapsone monotherapy. Three patients who had received the World Health Organization-recommended regimens of multidrug therapy (WHO/ MDT) relapsed as histoid leprosy 12-15 years after completion of treatment. In one patient, through mouse foot pad studies, the bacilli were found to be sensitive to rifampin and clofazimine and resistant to dapsone. In the other two patients mouse foot pad studies were inconclusive. The patients were re-started on WHO/ MDT. Two patients took regular treatment and improved, both clinically and bacteriologically. One patient was irregular in treatment, and 1 year after re-starting WHO/ MDT nodules were still present although the bacterial index had fallen slightly.

AB - The histoid type of leprosy has been described as occurring in lepromatous leprosy patients who relapse after many years of apparently successful dapsone monotherapy. Three patients who had received the World Health Organization-recommended regimens of multidrug therapy (WHO/ MDT) relapsed as histoid leprosy 12-15 years after completion of treatment. In one patient, through mouse foot pad studies, the bacilli were found to be sensitive to rifampin and clofazimine and resistant to dapsone. In the other two patients mouse foot pad studies were inconclusive. The patients were re-started on WHO/ MDT. Two patients took regular treatment and improved, both clinically and bacteriologically. One patient was irregular in treatment, and 1 year after re-starting WHO/ MDT nodules were still present although the bacterial index had fallen slightly.

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Relapse as histoid leprosy after receiving multidrug therapy (MDT); a report of three cases

Abstract

ASJC Scopus subject areas

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