Rehabilitation therapy and outcomes in acute respiratory failure: An observational pilot project

Jennifer M. Zanni, Radha Korupolu, Eddy Fan, Pranoti Pradhan, Kashif Janjua, Jeffrey B. Palmer, Roy G. Brower, Dale M. Needham

Research output: Contribution to journalArticlepeer-review

173 Scopus citations


Purpose: The aim of this study was to describe the frequency, physiologic effects, safety, and patient outcomes associated with traditional rehabilitation therapy in patients who require mechanical ventilation. Materials and Methods: Prospective observational report of consecutive patients ventilated 4 or more days and eligible for rehabilitation in a single medical intensive care unit (ICU) during a 13-week period was conducted. Results: Of the 32 patients who met the inclusion criteria, only 21 (66%) received physician orders for evaluation by rehabilitation services (physical and/or occupational therapy). Fifty rehabilitation treatments were provided to 19 patients on a median of 12% of medical ICU days per patient, with deep sedation and unavailability of rehabilitation staff representing major barriers to treatment. Physiologic changes during rehabilitation therapy were minimal. Joint contractures were frequent in the lower extremities and did not improve during hospitalization. In 53% and 79% of initial ICU assessments, muscle weakness was present in upper and lower extremities, respectively, with a decreased prevalence of 19% and 43% at hospital discharge, respectively. New impairments in physical function were common at hospital discharge. Conclusions: This pilot project illustrated important barriers to providing rehabilitation to mechanically ventilated patients in an ICU and impairments in strength, range of motion, and functional outcomes at hospital discharge.

Original languageEnglish (US)
Pages (from-to)254-262
Number of pages9
JournalJournal of Critical Care
Issue number2
StatePublished - Jun 2010


  • Contracture
  • Critical care
  • Early ambulation
  • Muscle weakness
  • Rehabilitation
  • Respiration, artificial
  • Respiratory insufficiency

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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