Regulatory T cells and the pursuit of self-tolerance

Allan D. Hess

doi:10.1182/blood-2007-08-107920

Regulatory T cells and the pursuit of self-tolerance

Allan D. Hess

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Failure of the CD4⁺CD25⁺Foxp3⁺ regulatory T-cell compartment to control immune reactivity to self-antigens leads to the development of chronic graft-versus-host disease largely mediated by donor-derived helper T cells that secrete proinflammatory cytokines.

Original language	English (US)
Pages (from-to)	3497-3498
Number of pages	2
Journal	Blood
Volume	110
Issue number	10
DOIs	https://doi.org/10.1182/blood-2007-08-107920
State	Published - Nov 15 2007

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2007-08-107920

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title = "Regulatory T cells and the pursuit of self-tolerance",

abstract = "Failure of the CD4+CD25+Foxp3+ regulatory T-cell compartment to control immune reactivity to self-antigens leads to the development of chronic graft-versus-host disease largely mediated by donor-derived helper T cells that secrete proinflammatory cytokines.",

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year = "2007",

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JO - Blood

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Regulatory T cells and the pursuit of self-tolerance

Abstract

ASJC Scopus subject areas

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