Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


The small subpopulation of breast cancer cells that possess the capability for self-renewal and formation of secondary tumours that recapitulate the heterogeneity of the primary tumour are referred to as tumour-initiating cells or BCSCs (breast cancer stem cells). The hypoxic tumour microenvironment and chemotherapy actively induce the BCSC phenotype. HIFs (hypoxia-inducible factors) are required and molecular mechanisms by which they promote the BCSC phenotype have recently been delineated. HIF inhibitors block chemotherapy-induced enrichment of BCSCs, suggesting that their use may improve the response to chemotherapy and increase the survival of breast cancer patients.

Original languageEnglish (US)
Pages (from-to)1037-1045
Number of pages9
JournalClinical Science
Issue number12
StatePublished - 2015

ASJC Scopus subject areas

  • Medicine(all)


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