Regulation of primary response genes

Trent Fowler, Ranjan Sen, Ananda L. Roy

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression. These "first responders" in the waves of transcription of signal-responsive genes play pivotal roles in a wide range of biological responses, including neuronal survival and plasticity, cardiac stress response, innate and adaptive immune responses, glucose metabolism, and oncogeneic transformation. Here we bring together recent advances and our current understanding of the signal-induced transcriptional and epigenetic regulation of PRGs.

Original languageEnglish (US)
Pages (from-to)348-360
Number of pages13
JournalMolecular Cell
Issue number3
StatePublished - Nov 4 2011
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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