Regulation of pathogenesis and immunity in helminth infections

Rick M. Maizels, Edward J. Pearce, David Artis, Maria Yazdanbakhsh, Thomas A. Wynn

Research output: Contribution to journalArticlepeer-review

Abstract

Helminths are multicellular eukaryotic parasites that infect over one quarter of the world's population. Through coevolution with the human immune system, these organisms have learned to exploit immunoregulatory pathways, resulting in asymptomatic tolerance of infections in many individuals. When infections and the resulting immune responses become dysregulated, however, acute and chronic pathologies often develop. A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved.

Original languageEnglish (US)
Pages (from-to)2059-2066
Number of pages8
JournalJournal of Experimental Medicine
Volume206
Issue number10
DOIs
StatePublished - Sep 28 2009
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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