TY - JOUR
T1 - Regulation of mitochondrial fusion and division
AU - Cerveny, Kara L.
AU - Tamura, Yasushi
AU - Zhang, Zhongyan
AU - Jensen, Robert E.
AU - Sesaki, Hiromi
N1 - Funding Information:
This work was supported by Damon Runyon Cancer Research Foundation (DRG1877–05) (K.L.C), Uehara Memorial Foundation (Y.T.), National Institutes of Health (R.E.J.), Johns Hopkins University and American Heart Association (H.S.).
PY - 2007/11
Y1 - 2007/11
N2 - In many organisms, ranging from yeast to humans, mitochondria fuse and divide to change their morphology in response to a multitude of signals. During the past decade, work using yeast and mammalian cells has identified much of the machinery required for fusion and division, including the dynamin-related GTPases - mitofusins (Fzo1p in yeast) and OPA1 (Mgm1p in yeast) for fusion and Drp1 (Dnm1p) for division. However, the mechanisms by which cells regulate these dynamic processes have remained largely unknown. Recent studies have uncovered regulatory mechanisms that control the activity, assembly, distribution and stability of the key components for mitochondrial fusion and division. In this review, we discuss how mitochondrial dynamics are controlled and how these events are coordinated with cell growth, mitosis, apoptosis and human diseases.
AB - In many organisms, ranging from yeast to humans, mitochondria fuse and divide to change their morphology in response to a multitude of signals. During the past decade, work using yeast and mammalian cells has identified much of the machinery required for fusion and division, including the dynamin-related GTPases - mitofusins (Fzo1p in yeast) and OPA1 (Mgm1p in yeast) for fusion and Drp1 (Dnm1p) for division. However, the mechanisms by which cells regulate these dynamic processes have remained largely unknown. Recent studies have uncovered regulatory mechanisms that control the activity, assembly, distribution and stability of the key components for mitochondrial fusion and division. In this review, we discuss how mitochondrial dynamics are controlled and how these events are coordinated with cell growth, mitosis, apoptosis and human diseases.
UR - http://www.scopus.com/inward/record.url?scp=36048945306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048945306&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2007.08.006
DO - 10.1016/j.tcb.2007.08.006
M3 - Review article
C2 - 17959383
AN - SCOPUS:36048945306
SN - 0962-8924
VL - 17
SP - 563
EP - 569
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 11
ER -