Regulation of Mitochondrial Cabsup2+esup Uptake

Elizabeth Murphy, Charles Steenbergen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Cabsup2+esup is a key modulator of both ATP production and cell death. Although mitochondrial Cabsup2+esup uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Cabsup2+esup uptake and efflux have been identified. The identification of the mitochondrial Cabsup2+esup uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Cabsup2+esup is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.

Original languageEnglish (US)
Pages (from-to)107-126
Number of pages20
JournalAnnual review of physiology
StatePublished - Feb 10 2021


  • Ca2+
  • energetics
  • mitochondria
  • sodium

ASJC Scopus subject areas

  • Physiology


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