Regulation of human T-Cell production of interleukin 2 by Leu 11 (CD16) positive large granular lymphocytes

Zahra Toossi, Michelle R. Paris, Scott F. Purvis, Jerrold J. Ellner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Peripheral blood large granular lymphocytes (LGL) expressing Leu 11 (CD16) antigen with potent natural killer cytotoxicity inhibited soluble antigen-induced T-cell production of interleukin 2 (IL-2). Depletion of Leu 11-reactive cells from T-cells doubled IL-2 activity (P <0.05). Leu 11 -enriched cells did not express high affinity IL-2 receptors nor did they deplete IL-2 activity from culture media. Upon addition in low ratios to Leu 11-depleted cells, Leu 11-enriched fractions increased antigen-induced IL-2 production three-fold (P <0.05), whereas at higher ratios IL-2 production was suppressed P <0.01. Additionally, adherent monocytes were increasingly accessory when added in graded numbers to Leu 11-depleted but not T-cell cultures. In the presence of small numbers (5%) of Leu 11-enriched cells, however, monocytes down-regulated IL-2 production of Leu 11-depleted cell cultures. Thus Leu 11-reactive lymphocytes have noncytotoxic functions and may play a major role in immunoregulation.

Original languageEnglish (US)
Pages (from-to)413-424
Number of pages12
JournalCellular Immunology
Issue number2
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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