Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by andronergic-anabolic steroids

Rexford S. Ahima; Richard E. Harlan

doi:10.1016/0006-8993(92)91226-5

Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by andronergic-anabolic steroids

Rexford S. Ahima, Richard E. Harlan

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30 Scopus citations

Abstract

To determine whether androenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.

Original language	English (US)
Pages (from-to)	311-314
Number of pages	4
Journal	Brain research
Volume	585
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(92)91226-5
State	Published - Jul 10 1992
Externally published	Yes

Keywords

Androgenic-anabolic steroid
Glucocorticoid receptor
Hippocampus
Rat

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(92)91226-5

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title = "Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by andronergic-anabolic steroids",

abstract = "To determine whether androenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.",

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AU - Harlan, Richard E.

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N2 - To determine whether androenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.

AB - To determine whether androenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.

KW - Androgenic-anabolic steroid

KW - Glucocorticoid receptor

KW - Hippocampus

KW - Rat

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Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by andronergic-anabolic steroids

Abstract

Keywords

ASJC Scopus subject areas

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