Abstract
Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous cellular signal, which is crucial in cancer. This review presents regulation of calcium signaling in lung cancer. Altered expression of specific Ca2+ channels and Ca2+-binding proteins are characterizing features of lung cancer, which regulate cell signaling pathway leading to cell proliferation or apoptosis. Chemoresistance is frequent in lung cancer. Altered endoplasmic reticulum Ca2+ homeostasis of lung cancer cell is correlated with drug resistance. Hypoxia has a vital role in tumor angiogenesis, metastasis, apoptosis. And Ca2+ channels are open induced by hypoxia with the increase of Ca2+ influx causing tumor growth.
Original language | English (US) |
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Pages (from-to) | 52-56 |
Number of pages | 5 |
Journal | Journal of Thoracic Disease |
Volume | 2 |
Issue number | 1 |
State | Published - 2010 |
Externally published | Yes |
Keywords
- Calcium
- Calcium channels
- Calcium-binding protein
- Endoplasmic reticulum
- Lung cancer
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine