Regulation of Body Weight by Malonyl-CoA in the CNS

S. Rodriguez, M. J. Wolfgang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Intermediary metabolites of fatty acid biosynthesis are used by the central nervous system to signal changes in body weight in response to alterations in dietary nutrients. This nutrient-sensing mechanism links cellular bioenergetics to complex animal behavior. The central molecule in this pathway, malonyl-coenzyme A (CoA), is the product of the rate-limiting and highly regulated step in fatty acid biosynthesis. Increased concentrations of hypothalamic malonyl-CoA, mediated by nutrient or endocrine cues, inhibit food intake and enhance peripheral energy expenditure resulting in a reduction in body weight. Conversely, the depletion of malonyl-CoA leads to an obese phenotype. Here, we describe the regulation and mechanism by which malonyl-CoA regulates body weight.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages3
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
StatePublished - Feb 15 2013


  • ACC
  • AMPK
  • Body weight
  • CNS
  • CPT1
  • FASN
  • Glucose
  • Malonyl-CoA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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