Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota, Gregg L. Semenza

Research output: Contribution to journalReview articlepeer-review

368 Scopus citations


Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.

Original languageEnglish (US)
Pages (from-to)15-26
Number of pages12
JournalCritical Reviews in Oncology/Hematology
Issue number1
StatePublished - Jul 2006


  • Arteriogenesis
  • Cancer
  • HIF-1
  • Ischemia
  • Prolyl hydroxylase
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology
  • Oncology


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