Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota; Gregg L. Semenza

doi:10.1016/j.critrevonc.2005.12.003

Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota, Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Review article › peer-review

368 Scopus citations

Abstract

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.

Original language	English (US)
Pages (from-to)	15-26
Number of pages	12
Journal	Critical Reviews in Oncology/Hematology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1016/j.critrevonc.2005.12.003
State	Published - Jul 2006

Keywords

Arteriogenesis
Cancer
HIF-1
Ischemia
Prolyl hydroxylase
Vascular endothelial growth factor

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.critrevonc.2005.12.003

Cite this

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title = "Regulation of angiogenesis by hypoxia-inducible factor 1",

abstract = "Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.",

keywords = "Arteriogenesis, Cancer, HIF-1, Ischemia, Prolyl hydroxylase, Vascular endothelial growth factor",

author = "Kiichi Hirota and Semenza, {Gregg L.}",

note = "Funding Information: The authors apologize for the inability to cite all of the important studies that have been performed in the field due to space limitations. Work in the authors{\textquoteright} laboratories is supported in part by grants from the National Institutes of Health (to G.L.S.) and by a grant-in-aid for scientific research from ministry of education, culture, sports, science and technology (to K.H.). ",

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AU - Semenza, Gregg L.

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PY - 2006/7

Y1 - 2006/7

N2 - Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.

AB - Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.

KW - Arteriogenesis

KW - Cancer

KW - HIF-1

KW - Ischemia

KW - Prolyl hydroxylase

KW - Vascular endothelial growth factor

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Regulation of angiogenesis by hypoxia-inducible factor 1

Abstract

Keywords

ASJC Scopus subject areas

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