TY - JOUR
T1 - Regulation of AMPA receptor trafficking and synaptic plasticity
AU - Anggono, Victor
AU - Huganir, Richard L.
N1 - Funding Information:
We apologize to those authors whose work was not cited due to space restrictions. Work in our laboratory is supported by grants from the National Institute of Health and the Howard Hughes Medical Institute (to R.L.H.). V.A. is supported by fellowships from the International Human Frontier Science Program ( LT00399/2008-L ) and the Australian National Health and Medical Research Council (ID: 477108 ).
PY - 2012/6
Y1 - 2012/6
N2 - AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the tightly regulated trafficking of AMPARs into and out of synapses. The life cycle of AMPARs from their biosynthesis, membrane trafficking, and synaptic targeting to their degradation are controlled by a series of orchestrated interactions with numerous intracellular regulatory proteins. Here we review recent progress made toward the understanding the regulation of AMPAR trafficking, focusing on the roles of several key intracellular AMPAR interacting proteins.
AB - AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the tightly regulated trafficking of AMPARs into and out of synapses. The life cycle of AMPARs from their biosynthesis, membrane trafficking, and synaptic targeting to their degradation are controlled by a series of orchestrated interactions with numerous intracellular regulatory proteins. Here we review recent progress made toward the understanding the regulation of AMPAR trafficking, focusing on the roles of several key intracellular AMPAR interacting proteins.
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U2 - 10.1016/j.conb.2011.12.006
DO - 10.1016/j.conb.2011.12.006
M3 - Review article
C2 - 22217700
AN - SCOPUS:84862325147
SN - 0959-4388
VL - 22
SP - 461
EP - 469
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 3
ER -