Regulation of adipogenesis and energy balance by PPARγ and PGC-1

B. M. Spiegelman, P. Puigserver, Z. Wu

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


There has been a great deal of recent progress in our understanding of the transcriptional control of adipogenesis. Current data suggest that fat cell differentiation involves an interplay between the C/EBP family of transcription factors and PPARγ. The thermogenic program of brown fat cells may also include a contribution from a new coactivator, PGC-1. Recent data suggests that this coactivator is responsible for activation of thermogenesis and oxidative metabolism in both brown fat and muscle. The PGC-1 dependent program includes both mitochondrial biogenesis and tissue-specific expression of uncoupling proteins.

Original languageEnglish (US)
JournalInternational Journal of Obesity
Issue numberSUPPL. 4
StatePublished - 2000
Externally publishedYes


  • Adipogenesis
  • Energy balance
  • Fat cells
  • PPARγ

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Regulation of adipogenesis and energy balance by PPARγ and PGC-1'. Together they form a unique fingerprint.

Cite this