Regulation and characterization of the Na+/H+ exchanger

Larry Fliegel; Rakhilya Murtazina; Pavel Dibrov; Carmen Harris; Andrea Moor; Francoise A. Fernandez-Rachubinski

doi:10.1139/bcb-76-5-735

Regulation and characterization of the Na⁺/H⁺ exchanger

Larry Fliegel, Rakhilya Murtazina, Pavel Dibrov, Carmen Harris, Andrea Moor, Francoise A. Fernandez-Rachubinski

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The Na⁺/H⁺ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H⁺ for one extracellular Na⁺. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na⁺/H⁺ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity.

Original language	English (US)
Pages (from-to)	735-741
Number of pages	7
Journal	Biochemistry and Cell Biology
Volume	76
Issue number	5
DOIs	https://doi.org/10.1139/bcb-76-5-735
State	Published - Dec 1 1998

Keywords

Cation translocation
Intracellular pH
Membrane protein
Na/H antiporter
Protein phosphorylation
Protein-protein interaction

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1139/bcb-76-5-735

Cite this

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abstract = "The Na+/H+ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H+ for one extracellular Na+. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na+/H+ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity.",

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AU - Dibrov, Pavel

AU - Harris, Carmen

AU - Moor, Andrea

AU - Fernandez-Rachubinski, Francoise A.

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AB - The Na+/H+ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H+ for one extracellular Na+. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na+/H+ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity.

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KW - Intracellular pH

KW - Membrane protein

KW - Na/H antiporter

KW - Protein phosphorylation

KW - Protein-protein interaction

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