Regulation and biological function of helminth-induced cytokine responses

Fred D. Finkelman; Edward J. Pearce; Joseph F. Urban; Alan Sher

doi:10.1016/S0167-5699(05)80018-0

Regulation and biological function of helminth-induced cytokine responses

Fred D. Finkelman
, Edward J. Pearce
, Joseph F. Urban
, Alan Sher

Research output: Contribution to journal › Article › peer-review

Abstract

The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the T_H2 subset of CD4⁺ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections T_H2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.

Original language	English (US)
Pages (from-to)	A62-A66
Journal	Immunology Today
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/S0167-5699(05)80018-0
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Immunology

Access to Document

10.1016/S0167-5699(05)80018-0

Cite this

@article{865e2996fe9a4fa99be95b24f138a2cc,

title = "Regulation and biological function of helminth-induced cytokine responses",

abstract = "The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.",

author = "Finkelman, \{Fred D.\} and Pearce, \{Edward J.\} and Urban, \{Joseph F.\} and Alan Sher",

note = "Funding Information: This work was supported in part by the Uniformed Services University of the Health Sciences Protocol No. R08308, National Instituteso f Health GrantsA 121328a nd A126150,a grant from the EdnaM cConnelC lark Foundation,a nd Dept of Agriculture CRIS 1265-34000-009T. he opinions and as-sertionsc ontainedh ereina ret heprivateo neso f theauthorsa nd are not to be construeda so fficial or reflectingt he viewso f any organizationo f the United Statesg overnment.W e thank Drs Alan Cheever, Robert Coffman, William Gause, Richard Jones, lldy Katona, Tim Mosmann, Kathleen Madden,William Paul and Antonella SvetiC for their contributions to our experiments and thoughts and for allowing us to mention their unpublished data.",

year = "1991",

doi = "10.1016/S0167-5699(05)80018-0",

language = "English (US)",

volume = "12",

pages = "A62--A66",

journal = "Immunology Today",

issn = "0167-5699",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Regulation and biological function of helminth-induced cytokine responses

AU - Finkelman, Fred D.

AU - Pearce, Edward J.

AU - Urban, Joseph F.

AU - Sher, Alan

N1 - Funding Information: This work was supported in part by the Uniformed Services University of the Health Sciences Protocol No. R08308, National Instituteso f Health GrantsA 121328a nd A126150,a grant from the EdnaM cConnelC lark Foundation,a nd Dept of Agriculture CRIS 1265-34000-009T. he opinions and as-sertionsc ontainedh ereina ret heprivateo neso f theauthorsa nd are not to be construeda so fficial or reflectingt he viewso f any organizationo f the United Statesg overnment.W e thank Drs Alan Cheever, Robert Coffman, William Gause, Richard Jones, lldy Katona, Tim Mosmann, Kathleen Madden,William Paul and Antonella SvetiC for their contributions to our experiments and thoughts and for allowing us to mention their unpublished data.

PY - 1991

Y1 - 1991

N2 - The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.

AB - The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.

UR - https://www.scopus.com/pages/publications/0025863765

UR - https://www.scopus.com/pages/publications/0025863765#tab=citedBy

U2 - 10.1016/S0167-5699(05)80018-0

DO - 10.1016/S0167-5699(05)80018-0

M3 - Article

C2 - 1829892

AN - SCOPUS:0025863765

SN - 0167-5699

VL - 12

SP - A62-A66

JO - Immunology Today

JF - Immunology Today

IS - 3

ER -

Regulation and biological function of helminth-induced cytokine responses

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this