TY - JOUR
T1 - Regression of Melanoma Nodules in a Patient Treated With Ranitidine
AU - Smith, Tom
AU - Clark, Jeffrey W.
AU - Popp, Martin B.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1987/10
Y1 - 1987/10
N2 - Human malignant melanoma may regress spontaneously or with immunotherapy, such as Calmette-Guerin bacillus, interferon alfa, interleukin-2, and interleukin-2 plus lymphokine-activated killer cells. Histamine type 2 receptor antagonists can modulate immune function by inhibiting suppressor T-cell induction and activity, and melanoma regressions have been reported after the use of cimetidine with coumarin or interferon alfa. This article describes the complete regression of melanoma nodules in a patient treated with ranitidine hydrochloride, another histamine type 2—receptor antagonist. Ranitidine and cimetidine should be considered to be possibly active immunotherapeutic agents in the design and evaluation of clinical trials.
AB - Human malignant melanoma may regress spontaneously or with immunotherapy, such as Calmette-Guerin bacillus, interferon alfa, interleukin-2, and interleukin-2 plus lymphokine-activated killer cells. Histamine type 2 receptor antagonists can modulate immune function by inhibiting suppressor T-cell induction and activity, and melanoma regressions have been reported after the use of cimetidine with coumarin or interferon alfa. This article describes the complete regression of melanoma nodules in a patient treated with ranitidine hydrochloride, another histamine type 2—receptor antagonist. Ranitidine and cimetidine should be considered to be possibly active immunotherapeutic agents in the design and evaluation of clinical trials.
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U2 - 10.1001/archinte.1987.00370100129020
DO - 10.1001/archinte.1987.00370100129020
M3 - Article
C2 - 3662709
AN - SCOPUS:0023200833
SN - 0003-9926
VL - 147
SP - 1815
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 10
ER -