Registration-derived estimates of local lung expansion as surrogates for regional ventilation

Joseph M. Reinhardt, Gary E. Christensen, Eric A. Hoffman, Kai Ding, Kunlin Cao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

25 Scopus citations

Abstract

The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian of the registration displacement field. We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, r2 = 0.89 during gas wash-in) in one animal.

Original languageEnglish (US)
Title of host publicationInformation Processing in Medical lmaging - 20th International Conference, IPMI 2007, Proceedings
PublisherSpringer Verlag
Pages763-774
Number of pages12
ISBN (Print)3540732721, 9783540732723
DOIs
StatePublished - 2007
Externally publishedYes
Event20th International Conference on Information Processing in Medical lmaging, IPMI 2007 - Kerkrade, Netherlands
Duration: Jul 2 2007Jul 6 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4584 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other20th International Conference on Information Processing in Medical lmaging, IPMI 2007
Country/TerritoryNetherlands
CityKerkrade
Period7/2/077/6/07

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science

Fingerprint

Dive into the research topics of 'Registration-derived estimates of local lung expansion as surrogates for regional ventilation'. Together they form a unique fingerprint.

Cite this