TY - GEN
T1 - Registration-derived estimates of local lung expansion as surrogates for regional ventilation
AU - Reinhardt, Joseph M.
AU - Christensen, Gary E.
AU - Hoffman, Eric A.
AU - Ding, Kai
AU - Cao, Kunlin
PY - 2007
Y1 - 2007
N2 - The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian of the registration displacement field. We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, r2 = 0.89 during gas wash-in) in one animal.
AB - The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian of the registration displacement field. We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, r2 = 0.89 during gas wash-in) in one animal.
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U2 - 10.1007/978-3-540-73273-0_63
DO - 10.1007/978-3-540-73273-0_63
M3 - Conference contribution
C2 - 17633746
AN - SCOPUS:38149075977
SN - 3540732721
SN - 9783540732723
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 763
EP - 774
BT - Information Processing in Medical lmaging - 20th International Conference, IPMI 2007, Proceedings
PB - Springer Verlag
T2 - 20th International Conference on Information Processing in Medical lmaging, IPMI 2007
Y2 - 2 July 2007 through 6 July 2007
ER -