TY - GEN
T1 - Registration-based measurement of regional expiration volume ratio using dynamic 4DCT imaging
AU - Du, Kaifang
AU - Ding, Kai
AU - Cao, Kunlin
AU - Bayouth, John E.
AU - Christensen, Gary E.
AU - Reinhardt, Joseph M.
PY - 2011
Y1 - 2011
N2 - Lung function depends on mechanical lung expansion and contraction during the respiratory cycle. Recently developed dynamic 4D CT imaging and 3D image registration can be used to analyze regional lung function, which are significant for lung disease diagnosis, treatment and lung ventilation change during radiation therapy. 4D CT images of the lung can be reconstructed at any respiratory phase point based on the breathing trace signal during image acquisition. In this paper, we propose an image registration-based technique for assessing regional pulmonary function during specified time interval and estimating regional expiration volume ratio using 4D CT. Data from four anesthetized mechanically-ventilated sheep and one human patient undergoing Radiation Therapy were analyzed. Sheep lung images were divided into 30 slabs in the ventral-dorsal direction with equal lung height to study the ventilation variation. We found that the mean values of expiration volume ratio across slabs demonstrate a similar pattern and lung tissue near dorsal part contracts more in the first expiratory phase. The reproducibility of regional lung function of one human patient was compared between end-expiration-to-end-inspiration pair and the phase pair spanning the first expiratory interval, in which the latter pair shows 30% higher reproducibility. The accuracy of image registration is assessed by 200 semi-automatically annotated lung landmarks. Sheep data show landmark error on the level of 0.8 mm after registration.
AB - Lung function depends on mechanical lung expansion and contraction during the respiratory cycle. Recently developed dynamic 4D CT imaging and 3D image registration can be used to analyze regional lung function, which are significant for lung disease diagnosis, treatment and lung ventilation change during radiation therapy. 4D CT images of the lung can be reconstructed at any respiratory phase point based on the breathing trace signal during image acquisition. In this paper, we propose an image registration-based technique for assessing regional pulmonary function during specified time interval and estimating regional expiration volume ratio using 4D CT. Data from four anesthetized mechanically-ventilated sheep and one human patient undergoing Radiation Therapy were analyzed. Sheep lung images were divided into 30 slabs in the ventral-dorsal direction with equal lung height to study the ventilation variation. We found that the mean values of expiration volume ratio across slabs demonstrate a similar pattern and lung tissue near dorsal part contracts more in the first expiratory phase. The reproducibility of regional lung function of one human patient was compared between end-expiration-to-end-inspiration pair and the phase pair spanning the first expiratory interval, in which the latter pair shows 30% higher reproducibility. The accuracy of image registration is assessed by 200 semi-automatically annotated lung landmarks. Sheep data show landmark error on the level of 0.8 mm after registration.
KW - image registration
KW - pulmonary
KW - regional
KW - ventilation
UR - http://www.scopus.com/inward/record.url?scp=80055059816&partnerID=8YFLogxK
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U2 - 10.1109/ISBI.2011.5872437
DO - 10.1109/ISBI.2011.5872437
M3 - Conference contribution
AN - SCOPUS:80055059816
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 424
EP - 428
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
Y2 - 30 March 2011 through 2 April 2011
ER -