TY - JOUR
T1 - Regional white matter change in pre-symptomatic Huntington's disease
T2 - A diffusion tensor imaging study
AU - Reading, Sarah A.J.
AU - Yassa, Michael A.
AU - Bakker, Arnold
AU - Dziorny, Adam C.
AU - Gourley, Lisa M.
AU - Yallapragada, Venu
AU - Rosenblatt, Adam
AU - Margolis, Russell L.
AU - Aylward, Elizabeth H.
AU - Brandt, Jason
AU - Mori, Susumu
AU - Van Zijl, Peter
AU - Bassett, Susan S.
AU - Ross, Christopher A.
N1 - Funding Information:
This work was supported by the National Institutes of Health (PO1 NS16375, C.A.R.), the Johns Hopkins University School of Medicine General Clinical Research Center (MO1-4400052, S.A.J.R.) from the National Center for Research Resources/NIH, the Huntington's Disease Society of America (Center of Excellence at Johns Hopkins) and The Johns Hopkins University Clinician Scientist Award Program (S.A.J.R.).
PY - 2005/10/30
Y1 - 2005/10/30
N2 - The pathology of Huntington's disease (HD) is characterized by diffuse brain atrophy, with the most substantial neuronal loss occurring in the caudate and putamen. Recent evidence suggests that there may be more widespread neuronal degeneration with significant involvement of extrastriate structures, including white matter. In this study of pre-symptomatic carriers of the HD genetic mutation, we have used diffusion tensor imaging to examine the integrity and organization of white matter in a group of individuals who previously demonstrated abnormalities in response to a functional magnetic resonance imaging paradigm. Our results indicate that, before the onset of manifest HD, there are regional decreases in fractional anisotropy, indicating early white matter disorganization.
AB - The pathology of Huntington's disease (HD) is characterized by diffuse brain atrophy, with the most substantial neuronal loss occurring in the caudate and putamen. Recent evidence suggests that there may be more widespread neuronal degeneration with significant involvement of extrastriate structures, including white matter. In this study of pre-symptomatic carriers of the HD genetic mutation, we have used diffusion tensor imaging to examine the integrity and organization of white matter in a group of individuals who previously demonstrated abnormalities in response to a functional magnetic resonance imaging paradigm. Our results indicate that, before the onset of manifest HD, there are regional decreases in fractional anisotropy, indicating early white matter disorganization.
KW - Diffusion tensor imaging
KW - Fractional anisotropy
KW - Magnetic resonance imaging
KW - Neuroimaging
KW - Neuronal degeneration
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U2 - 10.1016/j.pscychresns.2005.05.011
DO - 10.1016/j.pscychresns.2005.05.011
M3 - Article
C2 - 16199141
AN - SCOPUS:26644445690
SN - 0925-4927
VL - 140
SP - 55
EP - 62
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 1
ER -