Regional localization of histamine and histidine in the brain of the Rhesus monkey

Kenneth M. Taylor; Eduard Gfeller; Solomon H. Snyder

doi:10.1016/0006-8993(72)90624-5

Regional localization of histamine and histidine in the brain of the Rhesus monkey

Kenneth M. Taylor, Eduard Gfeller, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The development of a sensitive microassay has made possible the evaluation of histamine and histidine concentrations in discrete nuclei and other areas of the rhesus monkey brain. Within the hypothalamus the mammillary bodies and the supraoptic nucleus contained the highest concentration of histamine, which was about 4 times that found in the preoptic and paraventricular nuclei. In most brain regions the medially located portions contained more histamine than did the lateral areas. There was no correlation between histamine and histidine concentrations in most areas of the brain. Histidine was more uniformly distributed and generally occurred in concentrations 100 times those of histamine.

Original language	English (US)
Pages (from-to)	171-179
Number of pages	9
Journal	Brain research
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(72)90624-5
State	Published - Jun 8 1972

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(72)90624-5

Cite this

@article{8d178c8ed06e433c9e9ecbd66f1e9fc4,

title = "Regional localization of histamine and histidine in the brain of the Rhesus monkey",

abstract = "The development of a sensitive microassay has made possible the evaluation of histamine and histidine concentrations in discrete nuclei and other areas of the rhesus monkey brain. Within the hypothalamus the mammillary bodies and the supraoptic nucleus contained the highest concentration of histamine, which was about 4 times that found in the preoptic and paraventricular nuclei. In most brain regions the medially located portions contained more histamine than did the lateral areas. There was no correlation between histamine and histidine concentrations in most areas of the brain. Histidine was more uniformly distributed and generally occurred in concentrations 100 times those of histamine.",

author = "Taylor, {Kenneth M.} and Eduard Gfeller and Snyder, {Solomon H.}",

note = "Funding Information: This work was supported by U.S. Public Health Service Grants MH-18501, NS-07275 and GM-16492. Solomon H. Snyder is the recipient of NIMH Research Scientist Development Award K3-MH33128.",

year = "1972",

month = jun,

day = "8",

doi = "10.1016/0006-8993(72)90624-5",

language = "English (US)",

volume = "41",

pages = "171--179",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Regional localization of histamine and histidine in the brain of the Rhesus monkey

AU - Taylor, Kenneth M.

AU - Gfeller, Eduard

AU - Snyder, Solomon H.

N1 - Funding Information: This work was supported by U.S. Public Health Service Grants MH-18501, NS-07275 and GM-16492. Solomon H. Snyder is the recipient of NIMH Research Scientist Development Award K3-MH33128.

PY - 1972/6/8

Y1 - 1972/6/8

N2 - The development of a sensitive microassay has made possible the evaluation of histamine and histidine concentrations in discrete nuclei and other areas of the rhesus monkey brain. Within the hypothalamus the mammillary bodies and the supraoptic nucleus contained the highest concentration of histamine, which was about 4 times that found in the preoptic and paraventricular nuclei. In most brain regions the medially located portions contained more histamine than did the lateral areas. There was no correlation between histamine and histidine concentrations in most areas of the brain. Histidine was more uniformly distributed and generally occurred in concentrations 100 times those of histamine.

AB - The development of a sensitive microassay has made possible the evaluation of histamine and histidine concentrations in discrete nuclei and other areas of the rhesus monkey brain. Within the hypothalamus the mammillary bodies and the supraoptic nucleus contained the highest concentration of histamine, which was about 4 times that found in the preoptic and paraventricular nuclei. In most brain regions the medially located portions contained more histamine than did the lateral areas. There was no correlation between histamine and histidine concentrations in most areas of the brain. Histidine was more uniformly distributed and generally occurred in concentrations 100 times those of histamine.

UR - http://www.scopus.com/inward/record.url?scp=0015498133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015498133&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(72)90624-5

DO - 10.1016/0006-8993(72)90624-5

M3 - Article

C2 - 4624724

AN - SCOPUS:0015498133

SN - 0006-8993

VL - 41

SP - 171

EP - 179

JO - Brain research

JF - Brain research

IS - 1

ER -

Regional localization of histamine and histidine in the brain of the Rhesus monkey

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this