Regional differences in predictive accuracy of WHO immunologic failure criteria

Agnes N. Kiragga, Barbara Castelnuovo, Moses R. Kamya, Richard Moore, Yukari C. Manabe

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We compared the performance of the WHO immunologic criteria for treatment failure among Uganda and American patients. Antiretroviral treatment-naive patients with a CD4 T-cell count less than 200 cells/μl or AIDS at enrollment on a nonnucleoside reverse transcriptase inhibitors-based regimen for more than 1 year were selected. For all criteria, the positive predictive value was significantly higher in the American compared with the Ugandan patients. Population-specific guidelines should be developed using large African cohorts to identify more specific and sensitive criteria.

Original languageEnglish (US)
Pages (from-to)768-770
Number of pages3
Issue number6
StatePublished - Mar 27 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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