Abstract
We have examined the uptake of [3H]norepinephrine, [3H]5-hydroxytryptamine, and γ-amino[3H]butyric acid into 11 different regions of the brains of the spider and rhesus monkey. γ-Amino[3H]butyric acid was concentrated to a similar extent by all areas of monkey brain; failing to correlate with the endogenous concentration of the compound. [3H]Norepinephrine showed a regional localization similar to the endogenous catecholamine distribution, but with some differences. [3H]5-Hydroxytryptamine was concentrated by areas rich in endogenous 5-hydroxytryptamine as well as by areas rich in endogenous catecholamines. Although [3H]norepinephrine and [3H]5-hydroxytryptamine showed similar regional accumulations, there were some significant differences which suggest a specific uptake of [3H]5-hydroxytryptamine by serotoninergic neurons and of [3H]norepinephrine by norepinephrine or dopamine-containing nerve endings. The regional pattern of uptake of the 3 compounds studied was similar in the brains of rhesus and spider monkeys.
Original language | English (US) |
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Pages (from-to) | 469-477 |
Number of pages | 9 |
Journal | Brain research |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - Dec 1969 |
Externally published | Yes |
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology