Regional cerebral blood flow is not decreased in young adults with Down syndrome

M. B. Schapiro, K. F. Berman, D. R. Weinberger, S. I. Rapoport

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


An index of regional cerebral blood flow (rCBF) of cortical gray matter, initial slope (IS), was measured with the noninvasive xenon-133 inhalation method on 2 consecutive days in 11 healthy, noninstitutionalized subjects with trisomy 21 Down syndrome (DS) (mean age 28.0 years) and in 22 sex-matched, healthy volunteers (mean age 27.3 years). IS did not differ between groups for any lobar region. The ratio of rIS to hemispheric IS, and right/left and frontal/nonfrontal ratios also failed to show significant regional differences between groups. These results show that healthy young DS adults do not show abnormalities in rCBF, as measured with xenon-133 clearance, prior to the age (35 years) when neuropathological changes of Alzheimer's disease are reported to occur.

Original languageEnglish (US)
Pages (from-to)310-315
Number of pages6
JournalBrain Dysfunction
Issue number6
StatePublished - Dec 1 1989
Externally publishedYes


  • Brain
  • Cerebral blood flow
  • Down syndrome
  • Mental retardation
  • Trisomy 21
  • Xenon-133

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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