Regional Cerebral Blood Flow in Severe Developmental Dyslexia

Judith M. Rumsey, Karen Faith Berman, Martha B. Denckla, Susan D. Hamburger, Markus J. Kruesi, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Regional cerebral blood flow was measured under three task conditions in 14 men with severe developmental dyslexia and their control subjects using a xenon 133 inhalation technique. No group differences in overall level or in pattern of gray matter flow were seen under relatively undemanding cognitive conditions. Despite minimal group differences in performance, the dyslexic group showed an increased hemispheric asymmetry (left greater than right) on a semantic classification task and a reduced anteroposterior difference on a line orientation task relative to controls. The exaggerated asymmetry suggests the possibility of less efficient information processing or inadequate bihemispheric integration. The reduced anteroposterior gradient may reflect a deficit in the ability of frontal systems to respond adequately to cognitive demands.

Original languageEnglish (US)
Pages (from-to)1144-1150
Number of pages7
JournalArchives of neurology
Issue number11
StatePublished - Nov 1987
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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