Regional cerebral blood flow and glucose utilization during hypocapnia and adenosine-induced hypotension in the rat

J. Waaben, B. Husum, A. J. Hansen, A. Gjedde

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Hypocapnia and induced hypotension have been claimed by some to cause cerebral hypoxia because of insufficient perfusion. Regional cerebral blood flow (rCBF) and regional cerebral glucose utilization (rCMR(glc)) were measured simultaneously in the same animal subjected to hypocapnia or hypocapnia combined with induced arterial hypotension. The rCMR(glc) was measured with (3H) deoxyglucose and the rCBF with (14C) iodoantipyrine with the use of tissue biopsy methods and scintillation counting. Nineteen male Wistar rats were anesthetized with halothane and artificially ventilated. Anesthesia was maintained with nitrous oxide/oxygen (70 : 30) and succinylcholine. Six rats were maintained at normocapnia, six rats were ventilated to a Pa(CO2) of 20 mmHg, and seven animals were ventilated to (Pa(CO2)) 20 mmHg combined with arterial hypotension of 50 mmHg (mean blood pressure) induced by infusion of adenosine. Although hypocapnia alone did not cause a statistically significant decrease of rCBF except in hippocampus, hypocapnia combined with hypotension resulted in a significant reduction of rCBF in four of seven regions when compared with hypocapnia alone; rCMR(glc) values were unchanged during hypocapnia. However, the addition of hypotension induced by adenosine led to a significant decline of glucose utilization in five of seven brain regions. In the present study the authors observed no increase of regional glucose utilization and hence no signs of cerebral ischemia during hypocapnia alone or combined with hypotension induced by adenosine.

Original languageEnglish (US)
Pages (from-to)299-304
Number of pages6
Issue number2
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Regional cerebral blood flow and glucose utilization during hypocapnia and adenosine-induced hypotension in the rat'. Together they form a unique fingerprint.

Cite this