Abstract
Regenerative medicine strategies for the restoration of functional tissue have evolved from the concept of ex vivo creation of engineered tissue toward the broader concept of in vivo induction of functional tissue reconstruction. Multidisciplinary approaches are being investigated to achieve this goal using evolutionarily conserved principles of stem cell biology, developmental biology and immunology, current methods of engineering and medicine. This evolution from ex vivo tissue engineering to the manipulation of fundamental in vivo tenets of development and regeneration has the potential to capitalize upon the incredibly complex and only partially understood ability of cells to adapt, proliferate, self-organize and differentiate into functional tissue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 767-775 |
| Number of pages | 9 |
| Journal | Regenerative Medicine |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 2016 |
| Externally published | Yes |
Keywords
- bioscaffolds
- blastema
- constructive remodeling
- development
- microenvironmental niche
- regeneration
- stem cell
- tissue engineering
- whole-organ engineering
ASJC Scopus subject areas
- Biomedical Engineering
- Embryology