Regeneration of oligodendroglia during recovery from demyelinating disease

Robert M. Herndon; Donald L. Price; Leslie P. Weiner

doi:10.1126/science.190678

Regeneration of oligodendroglia during recovery from demyelinating disease

Robert M. Herndon, Donald L. Price, Leslie P. Weiner

School of Medicine

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Abstract

Infection of mice with the JHM strain of mouse hepatitis virus causes demyelination as a result of a cytolytic infection of oligodendroglia. In recovery, animals show remyelination, which could result either from surviving oligodendrocytes extending their territory or by generation of new oligodendroglia. Electron microscopic autoradiographic studies with ³H-labeled thymidine demonstrate that the cells associated with remyelination are newly generated oligodendroglia.

Original language	English (US)
Pages (from-to)	693-694
Number of pages	2
Journal	Science
Volume	195
Issue number	4279
DOIs	https://doi.org/10.1126/science.190678
State	Published - 1977

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title = "Regeneration of oligodendroglia during recovery from demyelinating disease",

abstract = "Infection of mice with the JHM strain of mouse hepatitis virus causes demyelination as a result of a cytolytic infection of oligodendroglia. In recovery, animals show remyelination, which could result either from surviving oligodendrocytes extending their territory or by generation of new oligodendroglia. Electron microscopic autoradiographic studies with 3H-labeled thymidine demonstrate that the cells associated with remyelination are newly generated oligodendroglia.",

author = "Herndon, {Robert M.} and Price, {Donald L.} and Weiner, {Leslie P.}",

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AU - Price, Donald L.

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AB - Infection of mice with the JHM strain of mouse hepatitis virus causes demyelination as a result of a cytolytic infection of oligodendroglia. In recovery, animals show remyelination, which could result either from surviving oligodendrocytes extending their territory or by generation of new oligodendroglia. Electron microscopic autoradiographic studies with 3H-labeled thymidine demonstrate that the cells associated with remyelination are newly generated oligodendroglia.

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Regeneration of oligodendroglia during recovery from demyelinating disease

Abstract

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