Reevaluating the Role of LTD in Cerebellar Motor Learning

Martijn Schonewille, Zhenyu Gao, Henk Jan Boele, Maria F. Vinueza Veloz, Wardell E. Amerika, Antonia A.M. Šimek, Marcel T. De Jeu, Jordan P. Steinberg, Kogo Takamiya, Freek E. Hoebeek, David J. Linden, Richard L. Huganir, Chris I. De Zeeuw

Research output: Contribution to journalArticlepeer-review

216 Scopus citations


Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different cerebellar coordination tasks (adaptation of the vestibulo-ocular reflex, eyeblink conditioning, and locomotion learning on the Erasmus Ladder), we show that there is no motor learning impairment in these mutant mice that lack PF-PC LTD. These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
Issue number1
StatePublished - Apr 14 2011

ASJC Scopus subject areas

  • Neuroscience(all)


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