@article{55159a09100d4233843d8dae0666136c,
title = "Reevaluating the Role of LTD in Cerebellar Motor Learning",
abstract = "Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different cerebellar coordination tasks (adaptation of the vestibulo-ocular reflex, eyeblink conditioning, and locomotion learning on the Erasmus Ladder), we show that there is no motor learning impairment in these mutant mice that lack PF-PC LTD. These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning.",
author = "Martijn Schonewille and Zhenyu Gao and Boele, {Henk Jan} and {Vinueza Veloz}, {Maria F.} and Amerika, {Wardell E.} and {\v S}imek, {Antonia A.M.} and {De Jeu}, {Marcel T.} and Steinberg, {Jordan P.} and Kogo Takamiya and Hoebeek, {Freek E.} and Linden, {David J.} and Huganir, {Richard L.} and {De Zeeuw}, {Chris I.}",
note = "Funding Information: We kindly thank R. Avila Freire, M. Rutteman, D. Smeets, J. van der Burg, E. Haasdijk, and E. Goedknegt for their technical assistance, and we kindly thank the Dutch Organization for Medical Sciences (F.E.H., C.I.D.Z.), Life Sciences (M.S., F.E.H., C.I.D.Z.), Erasmus University Rotterdam Fellowship program (M.S., F.E.H.), Senter (Neuro-Bsik, C.I.D.Z.), Prinses Beatrix Fonds (C.I.D.Z.), the SENSOPAC program, C7 and CEREBNET of the European Community (C.I.D.Z.), the United States Public Health Service MH51106 (D.J.L.) and NS36715 (R.L.H.), and the Howard Hughes Medical Institute (R.L.H.) for their financial support. H.J.B. and C.I.D.Z. were supported by Neurasmus B.V. We kindly thank Toyama (Toyama Chemical Co. Ltd., Tokyo, Japan) for providing the T-588. ",
year = "2011",
month = apr,
day = "14",
doi = "10.1016/j.neuron.2011.02.044",
language = "English (US)",
volume = "70",
pages = "43--50",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",
}