Reduction of contact factors in sickle cell disease

Erlinda M. Gordon, Bruce L. Klein, Brian W. Berman, Sarh E. Strandjord, Joseph E. Simon, Peter F. Coccia

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Surface-mediated reactions of clotting were compared in 21 black children with homozygous sickle cell disease, 12 age-matched controls, and 15 adults. Both the coagulant and antigen titers of Hageman factor (factor XII) were decreased in asymptomatic patients compared with those in the control groups. These findings were associated with slight but significant reduction in the plasma titers of prekallikrein and high molecular weight kininogen. A further decrease from the initially low titers of these contact factors was observed during vaso-occlusive crises. Additionally, we observed a disparate relationship between Hageman factor coagulant activity and its antigen titers. These data provide evidence for reduction of the contact factors in patients with homozygous sickle cell disease.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalThe Journal of pediatrics
Issue number3
StatePublished - Mar 1985
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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