Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats

Ellen E. Ladenheim; Robert C. Speth; Robert C. Ritter

doi:10.1016/0006-8993(88)90675-0

Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats

Ellen E. Ladenheim, Robert C. Speth, Robert C. Ritter

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Cholecystokinin octapeptide (CCK-8) binding sites were examined in the caudal hindbrain of unilaterally nodosectomized and intact rats by in vitro autoradiography with ¹²⁵I-CCK-8. Unilateral nodosectomy caused a significant reduction in CCK-8 binding in the caudal medial nucleus of the solitary tract (NST) on the side ipsilateratal to the node gangliosectomy. Examination of other caudal hindbrain regions exhibiting CCK-8 binding did not reveal changes in binding in nodosectomized animals compared to controls. These findings suggest that the CCK receptors in this brain region may be located on terminals of vagal afferent neurons.

Original language	English (US)
Pages (from-to)	125-129
Number of pages	5
Journal	Brain research
Volume	474
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90675-0
State	Published - Nov 22 1988
Externally published	Yes

Keywords

Cholecystokinin
Nervus vagus
Nodose ganglion
Nucleus tractus solitarii
Receptor
rat

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)90675-0

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@article{3b012aef0e6e4262a523414da66841a1,

title = "Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats",

abstract = "Cholecystokinin octapeptide (CCK-8) binding sites were examined in the caudal hindbrain of unilaterally nodosectomized and intact rats by in vitro autoradiography with 125I-CCK-8. Unilateral nodosectomy caused a significant reduction in CCK-8 binding in the caudal medial nucleus of the solitary tract (NST) on the side ipsilateratal to the node gangliosectomy. Examination of other caudal hindbrain regions exhibiting CCK-8 binding did not reveal changes in binding in nodosectomized animals compared to controls. These findings suggest that the CCK receptors in this brain region may be located on terminals of vagal afferent neurons.",

keywords = "Cholecystokinin, Nervus vagus, Nodose ganglion, Nucleus tractus solitarii, Receptor, rat",

author = "Ladenheim, {Ellen E.} and Speth, {Robert C.} and Ritter, {Robert C.}",

note = "Funding Information: The authors thank S.J. Lucania of the Squibb Institute for Medical Research, Princeton, NJ, for the generous gift of CCK-8.This work was supported by NIH Grants NS 20561 and NS 21805.",

year = "1988",

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doi = "10.1016/0006-8993(88)90675-0",

language = "English (US)",

volume = "474",

pages = "125--129",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1",

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T1 - Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats

AU - Ladenheim, Ellen E.

AU - Speth, Robert C.

AU - Ritter, Robert C.

N1 - Funding Information: The authors thank S.J. Lucania of the Squibb Institute for Medical Research, Princeton, NJ, for the generous gift of CCK-8.This work was supported by NIH Grants NS 20561 and NS 21805.

PY - 1988/11/22

Y1 - 1988/11/22

N2 - Cholecystokinin octapeptide (CCK-8) binding sites were examined in the caudal hindbrain of unilaterally nodosectomized and intact rats by in vitro autoradiography with 125I-CCK-8. Unilateral nodosectomy caused a significant reduction in CCK-8 binding in the caudal medial nucleus of the solitary tract (NST) on the side ipsilateratal to the node gangliosectomy. Examination of other caudal hindbrain regions exhibiting CCK-8 binding did not reveal changes in binding in nodosectomized animals compared to controls. These findings suggest that the CCK receptors in this brain region may be located on terminals of vagal afferent neurons.

AB - Cholecystokinin octapeptide (CCK-8) binding sites were examined in the caudal hindbrain of unilaterally nodosectomized and intact rats by in vitro autoradiography with 125I-CCK-8. Unilateral nodosectomy caused a significant reduction in CCK-8 binding in the caudal medial nucleus of the solitary tract (NST) on the side ipsilateratal to the node gangliosectomy. Examination of other caudal hindbrain regions exhibiting CCK-8 binding did not reveal changes in binding in nodosectomized animals compared to controls. These findings suggest that the CCK receptors in this brain region may be located on terminals of vagal afferent neurons.

KW - Cholecystokinin

KW - Nervus vagus

KW - Nodose ganglion

KW - Nucleus tractus solitarii

KW - Receptor

KW - rat

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AN - SCOPUS:0024209052

SN - 0006-8993

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JO - Brain research

JF - Brain research

IS - 1

ER -

Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats

Abstract

Keywords

ASJC Scopus subject areas

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