Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac

Tanya J. Lehky; Michael C. Levin; Ryuji Kubota; Richard N. Bamford; Alfred N. Flerlage; Samantha S. Soldan; Thomas P. Leist; Andrew Xavier; Jeffrey D. White; Margaret Brown; Thomas A. Fleisher; Lois E. Top; Susan Light; Henry F. McFarland; Thomas A. Waldmann; Steven Jacobson

Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac

Tanya J. Lehky, Michael C. Levin, Ryuji Kubota, Richard N. Bamford, Alfred N. Flerlage, Samantha S. Soldan, Thomas P. Leist, Andrew Xavier, Jeffrey D. White, Margaret Brown, Thomas A. Fleisher, Lois E. Top, Susan Light, Henry F. McFarland, Thomas A. Waldmann, Steven Jacobson

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease that results from an interaction of retroviral infection and immune activation. In this study, five doses (1 mg/kg) of humanized anti-Tac antibody were administered to 9 HAM/TSP patients at weeks 0, 2, 6, 10, and 14. Preliminary immunological studies on HAM/TSP patients treated with humanized anti-Tac indicate that there is a selective down-regulation of activated T cells and a decrease in the HTLV-I viral load in peripheral blood lymphocytes, most likely through the selective removal of HTLV-I-infected, activated CD4⁺ lymphocytes.

Original language	English (US)
Pages (from-to)	942-947
Number of pages	6
Journal	Annals of Neurology
Volume	44
Issue number	6
State	Published - Dec 1998
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

Cite this

Lehky, T. J., Levin, M. C., Kubota, R., Bamford, R. N., Flerlage, A. N., Soldan, S. S., Leist, T. P., Xavier, A., White, J. D., Brown, M., Fleisher, T. A., Top, L. E., Light, S., McFarland, H. F., Waldmann, T. A., & Jacobson, S. (1998). Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac. Annals of Neurology, 44(6), 942-947.

Lehky, TJ, Levin, MC, Kubota, R, Bamford, RN, Flerlage, AN, Soldan, SS, Leist, TP, Xavier, A, White, JD, Brown, M, Fleisher, TA, Top, LE, Light, S, McFarland, HF, Waldmann, TA & Jacobson, S 1998, 'Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac', Annals of Neurology, vol. 44, no. 6, pp. 942-947.

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title = "Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac",

abstract = "Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease that results from an interaction of retroviral infection and immune activation. In this study, five doses (1 mg/kg) of humanized anti-Tac antibody were administered to 9 HAM/TSP patients at weeks 0, 2, 6, 10, and 14. Preliminary immunological studies on HAM/TSP patients treated with humanized anti-Tac indicate that there is a selective down-regulation of activated T cells and a decrease in the HTLV-I viral load in peripheral blood lymphocytes, most likely through the selective removal of HTLV-I-infected, activated CD4+ lymphocytes.",

author = "Lehky, {Tanya J.} and Levin, {Michael C.} and Ryuji Kubota and Bamford, {Richard N.} and Flerlage, {Alfred N.} and Soldan, {Samantha S.} and Leist, {Thomas P.} and Andrew Xavier and White, {Jeffrey D.} and Margaret Brown and Fleisher, {Thomas A.} and Top, {Lois E.} and Susan Light and McFarland, {Henry F.} and Waldmann, {Thomas A.} and Steven Jacobson",

year = "1998",

month = dec,

language = "English (US)",

volume = "44",

pages = "942--947",

journal = "Annals of Neurology",

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publisher = "John Wiley and Sons Inc.",

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T1 - Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac

AU - Lehky, Tanya J.

AU - Levin, Michael C.

AU - Kubota, Ryuji

AU - Bamford, Richard N.

AU - Flerlage, Alfred N.

AU - Soldan, Samantha S.

AU - Leist, Thomas P.

AU - Xavier, Andrew

AU - White, Jeffrey D.

AU - Brown, Margaret

AU - Fleisher, Thomas A.

AU - Top, Lois E.

AU - Light, Susan

AU - McFarland, Henry F.

AU - Waldmann, Thomas A.

AU - Jacobson, Steven

PY - 1998/12

Y1 - 1998/12

N2 - Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease that results from an interaction of retroviral infection and immune activation. In this study, five doses (1 mg/kg) of humanized anti-Tac antibody were administered to 9 HAM/TSP patients at weeks 0, 2, 6, 10, and 14. Preliminary immunological studies on HAM/TSP patients treated with humanized anti-Tac indicate that there is a selective down-regulation of activated T cells and a decrease in the HTLV-I viral load in peripheral blood lymphocytes, most likely through the selective removal of HTLV-I-infected, activated CD4+ lymphocytes.

AB - Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease that results from an interaction of retroviral infection and immune activation. In this study, five doses (1 mg/kg) of humanized anti-Tac antibody were administered to 9 HAM/TSP patients at weeks 0, 2, 6, 10, and 14. Preliminary immunological studies on HAM/TSP patients treated with humanized anti-Tac indicate that there is a selective down-regulation of activated T cells and a decrease in the HTLV-I viral load in peripheral blood lymphocytes, most likely through the selective removal of HTLV-I-infected, activated CD4+ lymphocytes.

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AN - SCOPUS:0031770389

SN - 0364-5134

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 6

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Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac

Abstract

ASJC Scopus subject areas

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