Reduced serum pyridoxine and 25-hydroxyvitamin D levels in adults with chronic pruritic dermatoses

Shilpa Gopinath, Nishadh Sutaria, Zachary A. Bordeaux, Varsha Parthasarathy, Junwen Deng, Matthew T. Taylor, Melika Marani, Kevin Lee, Thomas Pritchard, Ali Alajmi, Waleed Adawi, Olusola O. Oladipo, Yevgeniy R. Semenov, Martin Alphonse, Shawn G. Kwatra

Research output: Contribution to journalArticlepeer-review


Little is known about the role nutritional factors play in the pathogenesis of chronic pruritic dermatoses (CPD). In this study, we analyzed nutritional deficiencies in CPD patients compared to matched controls. We conducted a population-based study from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2006. The main outcomes of the study were laboratory data on serum vitamin levels in participants who answered affirmatively to the questionnaires on CPD as well as matched healthy controls. We identified 877 cases of CPD among 9817 adults in the US aged 20 to 59 years. These findings revealed a slightly higher percentage of females with CPD. Low vitamin B6 (OR 0.697; 95% CI: 0.696–0.699, p = 0.025) and vitamin D (OR 0.794; 95% CI: 0.789–0.799, p = 0.037) levels were associated with a higher rate of CPD compared to healthy controls. Our study suggests that low levels of Vitamin B6 and Vitamin D inversely correlates with the presence of CPD. These vitamin deficiencies suggest further studies on the effect of vitamin supplementation may help in patients with CPD.

Original languageEnglish (US)
Pages (from-to)1771-1776
Number of pages6
JournalArchives of Dermatological Research
Issue number6
StatePublished - Aug 2023


  • Atopic dermatitis
  • Chronic pruritus
  • Itch
  • Pyridoxine
  • Vitamin B6
  • Vitamin D

ASJC Scopus subject areas

  • Dermatology


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