TY - JOUR
T1 - Reduced gastrin releasing peptide in cerebrospinal fluid after recovery from bulimia nervosa
AU - Frank, G. K.
AU - Kaye, W. H.
AU - Ladenheim, E. E.
AU - McConaha, C.
N1 - Funding Information:
Supported in part by grants from NIMH #2 R01 MH 42984-09 ``The Neurobiology of Feeding Behavior in Bulimia''; Children's Hospital Clinical Research Center, Pittsburgh, PA (#5M01 RR00084), and NIMH #2 R01 MH 46001-07A1 ``Serotonin: A Trait Disturbance in Anorexia Nervosa''.
PY - 2001
Y1 - 2001
N2 - People with anorexia (AN) and bulimia nervosa (BN) have altered patterns of eating. It is possible that alterations of the neuropeptide gastrin releasing peptide (GRP), a bombesin (BBS) -like peptide with potent central anorexigenic activity, could contribute to disturbed eating behavior. To avoid the confounding effects of pathologic eating behavior, we measured cerebrospinal fluid (CSF) GRP concentrations in women who were long-term recovered (> 1 year, normal weight, and regular menstrual cycles, no bingeing or purging) from AN (REC AN, N = 12) or BN (REC BN, N = 21) compared to healthy control women (NC, N = 15). CSF GRP was significantly lower (X2 = 9.41(3), p < 0.01) in REC BN (9.6 ± 3.1 pg/ml) compared to NC (13.4 ± 5.5 pg/ml) and REC AN (11.6 ± 2.9 pg/ml). Persistent GRP abnormalities after recovery from BN raise the possibility that this alteration might be trait-related and contribute to episodic hyperphagia in BN.
AB - People with anorexia (AN) and bulimia nervosa (BN) have altered patterns of eating. It is possible that alterations of the neuropeptide gastrin releasing peptide (GRP), a bombesin (BBS) -like peptide with potent central anorexigenic activity, could contribute to disturbed eating behavior. To avoid the confounding effects of pathologic eating behavior, we measured cerebrospinal fluid (CSF) GRP concentrations in women who were long-term recovered (> 1 year, normal weight, and regular menstrual cycles, no bingeing or purging) from AN (REC AN, N = 12) or BN (REC BN, N = 21) compared to healthy control women (NC, N = 15). CSF GRP was significantly lower (X2 = 9.41(3), p < 0.01) in REC BN (9.6 ± 3.1 pg/ml) compared to NC (13.4 ± 5.5 pg/ml) and REC AN (11.6 ± 2.9 pg/ml). Persistent GRP abnormalities after recovery from BN raise the possibility that this alteration might be trait-related and contribute to episodic hyperphagia in BN.
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U2 - 10.1006/appe.2001.0407
DO - 10.1006/appe.2001.0407
M3 - Article
C2 - 11562153
AN - SCOPUS:0034877421
SN - 0195-6663
VL - 37
SP - 9
EP - 14
JO - Appetite
JF - Appetite
IS - 1
ER -