Redox-dependent signal transduction

Toren Finkel

doi:10.1016/S0014-5793(00)01669-0

Redox-dependent signal transduction

Toren Finkel

Research output: Contribution to journal › Article › peer-review

478 Scopus citations

Abstract

Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand-stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants. Copyright (C) 2000 Federation of European Biochemical Societies.

Original language	English (US)
Pages (from-to)	52-54
Number of pages	3
Journal	FEBS Letters
Volume	476
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(00)01669-0
State	Published - Jun 30 2000
Externally published	Yes

Keywords

NADPH oxidase
Peroxide
Rac1
Redox
Signal transduction

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/S0014-5793(00)01669-0

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abstract = "Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand-stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants. Copyright (C) 2000 Federation of European Biochemical Societies.",

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Y1 - 2000/6/30

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AB - Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand-stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants. Copyright (C) 2000 Federation of European Biochemical Societies.

KW - NADPH oxidase

KW - Peroxide

KW - Rac1

KW - Redox

KW - Signal transduction

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DO - 10.1016/S0014-5793(00)01669-0

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JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Redox-dependent signal transduction

Abstract

Keywords

ASJC Scopus subject areas

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