Redefining the roles of the FtsZ-ring in bacterial cytokinesis

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


In most bacteria, cell division relies on the functions of an essential protein, FtsZ. FtsZ polymerizes at the future division site to form a ring-like structure, termed the Z-ring, that serves as a scaffold to recruit all other division proteins, and possibly generates force to constrict the cell. The scaffolding function of the Z-ring is well established, but the force generating function has recently been called into question. Additionally, new findings have demonstrated that the Z-ring is more directly linked to cell wall metabolism than simply recruiting enzymes to the division site. Here we review these advances and suggest that rather than generating a rate-limiting constrictive force, the Z-ring's function may be redefined as an orchestrator of septum synthesis.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalCurrent Opinion in Microbiology
StatePublished - Dec 1 2016

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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