Recurrent seizures in immature rats: Effect on auditory and visual discrimination

John C. Neill; Liu Zhao; Matthew Sarkisian; Pushpa Tandon; Yili Yang; Carl E. Stafstrom; Gregory L. Holmes

doi:10.1016/0165-3806(96)00099-5

Recurrent seizures in immature rats: Effect on auditory and visual discrimination

John C. Neill, Liu Zhao, Matthew Sarkisian, Pushpa Tandon, Yili Yang, Carl E. Stafstrom, Gregory L. Holmes

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The effect of recurrent seizures in developing rats on subsequent long-term behavior was studied. Fifteen day old rats received a convulsant dosage of flurothyl three times daily for five consecutive days. When the rats were fully mature, they underwent behavioral testing using the water maze and auditory quality or location discrimination. With serial flurothyl administration seizure duration increased progressively but latency to seizure onset did not change. Compared to controls, flurothyl-treated rats had impaired performance in the water maze and on auditory location, but not on quality discrimination. Histological examination showed no gross cell loss in the hippocampus. This study demonstrates that serial seizures in the developing brain cause detrimental effects on visual and auditory spatial learning.

Original language	English (US)
Pages (from-to)	283-292
Number of pages	10
Journal	Developmental Brain Research
Volume	95
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(96)00099-5
State	Published - Sep 2 1996
Externally published	Yes

Keywords

Animal model
Auditory discrimination
Behavioral test

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/0165-3806(96)00099-5

Cite this

@article{6005df73da404299ab94e6e1871efa4b,

title = "Recurrent seizures in immature rats: Effect on auditory and visual discrimination",

abstract = "The effect of recurrent seizures in developing rats on subsequent long-term behavior was studied. Fifteen day old rats received a convulsant dosage of flurothyl three times daily for five consecutive days. When the rats were fully mature, they underwent behavioral testing using the water maze and auditory quality or location discrimination. With serial flurothyl administration seizure duration increased progressively but latency to seizure onset did not change. Compared to controls, flurothyl-treated rats had impaired performance in the water maze and on auditory location, but not on quality discrimination. Histological examination showed no gross cell loss in the hippocampus. This study demonstrates that serial seizures in the developing brain cause detrimental effects on visual and auditory spatial learning.",

keywords = "Animal model, Auditory discrimination, Behavioral test",

author = "Neill, {John C.} and Liu Zhao and Matthew Sarkisian and Pushpa Tandon and Yili Yang and Stafstrom, {Carl E.} and Holmes, {Gregory L.}",

note = "Funding Information: Supported by a grant from the NINDS (NS27984) and the Stephen Linn Fund (G.L.H.). We thank Bill Mcllvane for the donation of the stainless steel pellet structures.",

year = "1996",

month = sep,

day = "2",

doi = "10.1016/0165-3806(96)00099-5",

language = "English (US)",

volume = "95",

pages = "283--292",

journal = "Developmental Brain Research",

issn = "0165-3806",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Recurrent seizures in immature rats

T2 - Effect on auditory and visual discrimination

AU - Neill, John C.

AU - Zhao, Liu

AU - Sarkisian, Matthew

AU - Tandon, Pushpa

AU - Yang, Yili

AU - Stafstrom, Carl E.

AU - Holmes, Gregory L.

N1 - Funding Information: Supported by a grant from the NINDS (NS27984) and the Stephen Linn Fund (G.L.H.). We thank Bill Mcllvane for the donation of the stainless steel pellet structures.

PY - 1996/9/2

Y1 - 1996/9/2

N2 - The effect of recurrent seizures in developing rats on subsequent long-term behavior was studied. Fifteen day old rats received a convulsant dosage of flurothyl three times daily for five consecutive days. When the rats were fully mature, they underwent behavioral testing using the water maze and auditory quality or location discrimination. With serial flurothyl administration seizure duration increased progressively but latency to seizure onset did not change. Compared to controls, flurothyl-treated rats had impaired performance in the water maze and on auditory location, but not on quality discrimination. Histological examination showed no gross cell loss in the hippocampus. This study demonstrates that serial seizures in the developing brain cause detrimental effects on visual and auditory spatial learning.

AB - The effect of recurrent seizures in developing rats on subsequent long-term behavior was studied. Fifteen day old rats received a convulsant dosage of flurothyl three times daily for five consecutive days. When the rats were fully mature, they underwent behavioral testing using the water maze and auditory quality or location discrimination. With serial flurothyl administration seizure duration increased progressively but latency to seizure onset did not change. Compared to controls, flurothyl-treated rats had impaired performance in the water maze and on auditory location, but not on quality discrimination. Histological examination showed no gross cell loss in the hippocampus. This study demonstrates that serial seizures in the developing brain cause detrimental effects on visual and auditory spatial learning.

KW - Animal model

KW - Auditory discrimination

KW - Behavioral test

UR - http://www.scopus.com/inward/record.url?scp=0030565493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030565493&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(96)00099-5

DO - 10.1016/0165-3806(96)00099-5

M3 - Article

C2 - 8874904

AN - SCOPUS:0030565493

SN - 0165-3806

VL - 95

SP - 283

EP - 292

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 2

ER -

Recurrent seizures in immature rats: Effect on auditory and visual discrimination

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this