TY - JOUR
T1 - Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery
T2 - From the National Multiple Sclerosis Society Case Conference Proceedings
AU - Maldonado, Daniela A.Pimentel
AU - Lisak, Robert
AU - Galetta, Steven
AU - Balcer, Laura
AU - Varkey, Thomas
AU - Goodman, Andrew
AU - Graves, Jennifer
AU - Racke, Michael
AU - Zamvil, Scott S.
AU - Newsome, Scott
AU - Frohman, Elliot M.
AU - Frohman, Teresa C.
N1 - Funding Information:
This work was funded by the National Multiple Sclerosis Society. The authors thank Mr. Jason Ooi and Dr. Matthew Parsons for the development of Figure 1, which was funded by the Frohman Foundation: Innovating Precision Care Through Discovery in Molecular Medicine.
Funding Information:
This work was funded by the NationalMultiple Sclerosis Society. The authors thank Mr. Jason Ooi and Dr. Matthew Parsons for the development of Figure 1, which was funded by the Frohman Foundation: Innovating Precision Care Through Discovery in Molecular Medicine
Publisher Copyright:
© American Academy of Neurology.
PY - 2023/1/10
Y1 - 2023/1/10
N2 - We describe a woman with a history of relapsing acute optic neuritis and perineuritis. Testing failed to confirm a specific diagnosis; hence, she was diagnosed with seronegative neuromyelitis optica spectrum disorder and treated with the immunotherapy rituximab, later in conjunction with mycophenolate mofetil. She achieved a durable remission for 9 years until she presented with paresthesia affecting her left fifth digit, right proximal thigh, and left foot, while also reporting a 25-pound weight loss over the prior 3 months. New imaging demonstrated a longitudinally extensive and enhancing optic nerve, in conjunction with multifocal enhancing lesions within the spinal cord, in a skip-like distribution. The differential diagnosis is discussed.
AB - We describe a woman with a history of relapsing acute optic neuritis and perineuritis. Testing failed to confirm a specific diagnosis; hence, she was diagnosed with seronegative neuromyelitis optica spectrum disorder and treated with the immunotherapy rituximab, later in conjunction with mycophenolate mofetil. She achieved a durable remission for 9 years until she presented with paresthesia affecting her left fifth digit, right proximal thigh, and left foot, while also reporting a 25-pound weight loss over the prior 3 months. New imaging demonstrated a longitudinally extensive and enhancing optic nerve, in conjunction with multifocal enhancing lesions within the spinal cord, in a skip-like distribution. The differential diagnosis is discussed.
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U2 - 10.1212/NXI.0000000000200051
DO - 10.1212/NXI.0000000000200051
M3 - Article
C2 - 36357190
AN - SCOPUS:85141595608
SN - 2332-7812
VL - 10
JO - Neurology: Neuroimmunology and NeuroInflammation
JF - Neurology: Neuroimmunology and NeuroInflammation
IS - 1
M1 - e200051
ER -