TY - JOUR
T1 - Rectal Douching Practices Associated with Anal Intercourse
T2 - Implications for the Development of a Behaviorally Congruent HIV-Prevention Rectal Microbicide Douche
AU - Carballo-Dieguez, Alex
AU - Giguere, Rebecca
AU - Lentz, Cody
AU - Dolezal, Curtis
AU - Fuchs, Edward J.
AU - Hendrix, Craig W.
N1 - Funding Information:
We would like to thank the study participants, who took the time to complete the survey to contribute to our knowledge of douching practices, and the entire DREAM U19 study team for their input on the survey content. The study was funded by a U19 Grant under the Integrated Preclinical-Clinical Program for HIV Topical Microbicides (IPCP-HTM), Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) (AI113127). This work was also supported by a Center Grant from the NIMH to the HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute and Columbia University (P30-MH43520; PI: Remien, PhD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Funding Information:
Acknowledgements We would like to thank the study participants, who took the time to complete the survey to contribute to our knowledge of douching practices, and the entire DREAM U19 study team for their input on the survey content. The study was funded by a U19 Grant under the Integrated Preclinical-Clinical Program for HIV Topical Microbicides (IPCP-HTM), Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) (AI113127). This work was also supported by a Center Grant from the NIMH to the HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute and Columbia University (P30-MH43520; PI: Remien, PhD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Tenofovir administration via rectal douching results in higher rectal-mucosa drug concentration than oral administration. Many who engage in receptive anal intercourse (RAI) use cleansing rectal douches. To inform development of a behaviorally-congruent tenofovir douche, 4751 individuals ≥ 18 years-old, born male, from all US states/territories, who engaged in anal intercourse responded to an online survey. Of those who reported RAI in the prior 3 months, 80% douched beforehand, 82% within 1 h, mean 2.9 consecutive applications; 27% douched afterwards, 83% within 1 h, mean 1.7 consecutive applications. Among multidose users, 78% applied doses within 2 min, and 76% retained liquid < 1 min. Most used tap water (89%) in an enema bottle (50%) or rubber bulb (43%), and douched for cleanliness (97%), to avoid smelling bad (65%), and to enhance pleasure (24%). 98% reported high likelihood of using an HIV-prevention douche. An ideal product will protect within a user’s typical number of applications, within 1 h, and be dissolvable in tap water.
AB - Tenofovir administration via rectal douching results in higher rectal-mucosa drug concentration than oral administration. Many who engage in receptive anal intercourse (RAI) use cleansing rectal douches. To inform development of a behaviorally-congruent tenofovir douche, 4751 individuals ≥ 18 years-old, born male, from all US states/territories, who engaged in anal intercourse responded to an online survey. Of those who reported RAI in the prior 3 months, 80% douched beforehand, 82% within 1 h, mean 2.9 consecutive applications; 27% douched afterwards, 83% within 1 h, mean 1.7 consecutive applications. Among multidose users, 78% applied doses within 2 min, and 76% retained liquid < 1 min. Most used tap water (89%) in an enema bottle (50%) or rubber bulb (43%), and douched for cleanliness (97%), to avoid smelling bad (65%), and to enhance pleasure (24%). 98% reported high likelihood of using an HIV-prevention douche. An ideal product will protect within a user’s typical number of applications, within 1 h, and be dissolvable in tap water.
KW - Enemas
KW - HIV-prevention
KW - Rectal douching
KW - Rectal microbicides
UR - http://www.scopus.com/inward/record.url?scp=85056298070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056298070&partnerID=8YFLogxK
U2 - 10.1007/s10461-018-2336-6
DO - 10.1007/s10461-018-2336-6
M3 - Article
C2 - 30415431
AN - SCOPUS:85056298070
SN - 1090-7165
VL - 23
SP - 1484
EP - 1493
JO - AIDS and behavior
JF - AIDS and behavior
IS - 6
ER -