Reconstruction of the human cerebral cortex robust to white matter lesions: Method and validation

Navid Shiee, Pierre-Louis Bazin, Jennifer L. Cuzzocreo, Chuyang Ye, Bhaskar Kishore, Aaron Carass, Peter A. Calabresi, Daniel Salo Reich, Jerry L. Prince, Dzung Pham

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Cortical atrophy has been reported in a number of diseases, such as multiple sclerosis and Alzheimer's disease, that are also associated with white matter (WM) lesions. However, most cortical reconstruction techniques do not account for these pathologies, thereby requiring additional processing to correct for the effect of WM lesions. In this work, we introduce CRUISE+, an automated process for cortical reconstruction from magnetic resonance brain images with WM lesions. The process extends previously well validated methods to allow for multichannel input images and to accommodate for the presence of WM lesions. We provide new validation data and tools for measuring the accuracy of cortical reconstruction methods on healthy brains as well as brains with multiple sclerosis lesions. Using this data, we validate the accuracy of CRUISE+ and compare it to another state-of-the-art cortical reconstruction tool. Our results demonstrate that CRUISE+ has superior performance in the cortical regions near WM lesions, and similar performance in other regions. Hum Brain Mapp 35:3385-3401, 2014.

Original languageEnglish (US)
Pages (from-to)3385-3401
Number of pages17
JournalHuman Brain Mapping
Issue number7
StatePublished - Jul 2014


  • Cortical reconstruction
  • Cortical thickness
  • Lesion segmentation
  • Multiple sclerosis
  • WM lesions

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


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