TY - GEN
T1 - Reconstruction of myocardial architecture at high resolution using diffusion tensor MRI
AU - Scollan, D. F.
AU - Holmes, A. Alexander
AU - Zhang, Jianyang
AU - Winslow, Raimond L.
PY - 1999/12/1
Y1 - 1999/12/1
N2 - Diffusion tensor MRI (DTMRI) is a possible new means of elucidating the anatomic structure of the myocardium. It enjoys several advantages over traditional histological methods, including its ability to rapidly and nondestructively measure fiber architecture at very high resolution. However, quantitative validation of this MRI method has been lacking. Here, fiber orientations are estimated at the same locations using both DTMRI and histology in one formalin-fixed rabbit heart. Fiber orientations were statistically similar, differing on average by 5.3° (RMS) at any one location. The ventricular myofiber architecture of a number of normal rabbit hearts was then reconstructed using DTMRI into 3-D computer models for visualization. Myofiber organization appeared qualitatively similar to a previous high-resolution reconstruction using traditional histology.
AB - Diffusion tensor MRI (DTMRI) is a possible new means of elucidating the anatomic structure of the myocardium. It enjoys several advantages over traditional histological methods, including its ability to rapidly and nondestructively measure fiber architecture at very high resolution. However, quantitative validation of this MRI method has been lacking. Here, fiber orientations are estimated at the same locations using both DTMRI and histology in one formalin-fixed rabbit heart. Fiber orientations were statistically similar, differing on average by 5.3° (RMS) at any one location. The ventricular myofiber architecture of a number of normal rabbit hearts was then reconstructed using DTMRI into 3-D computer models for visualization. Myofiber organization appeared qualitatively similar to a previous high-resolution reconstruction using traditional histology.
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M3 - Conference contribution
AN - SCOPUS:0033322190
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -